SSH-005 for Hypotrichosis (congenital lack of hair)

Hypotrichosis is a congenital disease that refers to a condition in which there is little or no hair growth from birth, and it is estimated that there are approximately 10,000 patients in Japan. It is caused by a mutation in the IPH gene, and is inherited in an autosomal recessive manner. There is no established treatment that can fundamentally cure hypotrichosis.

NcPA (Natural cyclic lysophosphatidic acid) has already been used in cosmetics and its hair growth effects have been confirmed. 2ccPA which is a synthetic derivative of NcPA and API of SSH-005 has potential for use in congenital hypotrichosis. SANSHO is developing SSH-005 for hypotrichosis as an orphan drug and obtained a patent for the hair growth effects of 2ccPA.