SSI-002 for Idiopathic Pulmonary Fibrosis (IPF)

SSI-002 is a phospholipidmediator with inhibitory effects on ATX. ATX has been reported to promote lung fibrosis by converting LPC to the LPA. SSI-002 inhibited the fibroblast activity induced by the activation of ATX/LPA axis. The inhibitory effect of SSI-002 on fibroblast migration was strong, while its interference with epithelial cell migration was mild. Considering that epithelial cell migration is important for the recovery of lung tissue from injury, we believe that SSI-002 is a promising therapeutic candidate for pulmonary fibrosis.